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Benzene is a carcinogen that causes tumors in rodents at multiple sites and leukemia in humans (1). Several international organizations have conducted risk assessments based on exposure to benzene using various models. These models use a number of methods to estimate an exposure level associated with low levels of risk on the basis of cancer and noncancer end points. A risk level for cancer end points may be de ned as a unit risk value over a lifetime; noncancer end points may be de ned as a tolerable daily intake (TDI) or reference dose (Rfd). The uncertainty associated with the dietary exposure and an estimated low dose effect level has resulted in some uncertainty in the assessed health risk from dietary exposure to benzene. In 2006, Health Canada and the US FDA each assessed the risk associated with short-term exposure to beverages containing benzene at trace to low concentrations. In order to conduct the risk assessment, Health Canada used both a TDI value of 0.36 g/kg bw/day benzene that was based on experimental animal data available during the previous 1991 assessment as well as a range of oral slope factors calculated by the US EPA derived on the basis of a human cancer end point (leukemia). The slope factors were used to calculate the oral exposure (0.018 to 0.066 g/kg bw/day) associated with a cancer risk level of 10 6. A worst case probable daily intake (PDI) for children (5 to 11 years of age) was determined on the basis of daily consumption of a cherry- avored beverage with 18 ng/mL benzene. This product contained the highest benzene barcode add-in for excel freeware Barcode Add-In for Word & Excel Download and Installation
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